Cardioprotective potential of hydro-alcoholic extract of Nepeta hindostana (roth) on isoproternol induced myocardial Infarction in rats

The present study evaluated cardioprotective effect of hydro-alcoholic extract of Nepeta hindostana (NH), commonly know as badranjbuyeh in Unani medicine, in the experimental model of isoproterenol (ISO) induced- myocardial infarction. Wistar albino rats were divided in to four groups: sham control, ISO control, NH treatment group and ISO with NH treatment groups. NH was administered at doses of 25, 50 and 100 mg / 100 gm b w, orally for sixty days. On days 59th and 60th the rats of ISO control and NH treatment groups were administered ISO (20 mg / 100 mg b w) subcutaneously twice at an interval of 24 hrs. On 61 st the rats were sacrificed and serum was separated for biochemical parameters, creatinine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and lipid peroxide level and heart was processed for histopathalogical studies. The result suggests a promising cardioprotective role of NH treatment on isoproterenol-administered myocardial damage, which is probably mediated through NH antioxidant effects and contributing to prevention of acute myocardial infarction in rats.